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Caffeine: An Unconventional Treatment for Dry Eye

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Caffeine may have benefits that go beyond that early-morning jolt. Researchers in Japan have shown for the first time that caffeine can significantly increase the ability of the eye to produce tears, a finding that could have implications for millions of people with dry eye syndrome.

The study, which was published in Ophthalmology (Volume 119, page 972), examined 41 men and 37 women who were free of high blood pressure, dry eye syndrome and other eye conditions that could affect tear production. The volunteers were divided into two groups for two study sessions: One group received capsules containing caffeine in the first session and a placebo in the second, while the order was reversed for the second group. The amount of caffeine given, in 200 or 300 mg capsules, was based on body weight. (A cup of coffee contains about 150 mg of caffeine.)

The study found that all 78 participants experienced significantly increased tear volume after taking caffeine when compared with the placebo group. What’s more, the researchers reported that tear production was higher among individuals whose DNA samples showed two genetic variations that play important roles in caffeine metabolism.

The suggestion that caffeine could be a therapeutic drug for dry eye syndrome could eventually lead to improved treatments for this common ocular condition that may contribute to eye infections and vision problems.

Posted in Vision on December 6, 2013


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Health After 50 Alerts registered users may post comments and share experiences here at their own discretion. We regret that questions on individual health concerns to the editors cannot be answered in this space.

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Caffein eyedrops for high BP patients?

Posted by: DaveHarris | December 7, 2013 3:15 PM

2 unrelated questions: I have "normal" dry eyes due to aging, I guess, but an injury--corneal abrasion-- suffered 18 yrs ago results in a raised scar easily irritated by dryness, altitude any form of particle or allergen and of course chlorine during swimming. I treat the problem with lubricating eye ointment before bed every night. If I don't use the ointment overnight dryness can result in VERY irritated eye. Do you think caffeine would have any effect on this dry eye related problem? I drink strong coffee or espresso 2-3 cups a day.

2. I'd like to find some suggestion on the following. My sister was found to have a large malignant kidney tumor last June, and both the mass and her kidney were removed in August. My internist states there is no cause for alarm for me, that there is no other family history of kidney cancer -- neither of our parents(father died at nearly 92 and our mother is approaching her 91st birthday-- so far no cancer) had cancer at all -- what kind of scan or test IS available to me if I want to pursue preventive screening??? thank you to anyone who can direct me to a site or name for more information.

Posted by: patriciabrody | December 8, 2013 11:18 PM

Stainless steel does not readily corrode, rust or stain with water as ordinary steel does, but despite the name it is not fully stain-proof, most notably under low oxygen, high salinity, or poor circulation environments.[2] There are different grades and surface finishes of stainless steel to suit the environment the alloy must endure. Stainless steel is used where both the properties of steel and resistance to corrosion are required.

Posted by: sunitha | December 9, 2013 1:47 AM

check once the following information. High oxidation-resistance in air at ambient temperature is normally achieved with additions of a minimum of 13% (by weight) chromium, and up to 26% is used for harsh environments.[12] The chromium forms a passivation layer of chromium(III) oxide (Cr2O3) when exposed to oxygen. The layer is too thin to be

Posted by: | December 9, 2013 1:52 AM

HEllo your message above is cut off after "too thin to be.."

Can someone direct me to comments or information about Kidney Cancer sibling-related concerns? Thank you.

Posted by: | December 9, 2013 1:07 PM

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